Protein Carbamylation Renders High-Density Lipoprotein Dysfunctional
نویسندگان
چکیده
منابع مشابه
Myeloperoxidase-mediated dysfunctional high-density lipoprotein.
T he oxidation of lipoproteins plays an important role in atherogenesis. Most studies have focused on the oxidation of low-density lipoprotein, occurring to a significant extent in the arterial intima leading to the formation of the characteristic foam cell of the atherosclerotic plaque. 1 However, the oxidation of the proteins of high-density lipoprotein (HDL) is thought to substantially atten...
متن کاملDysfunctional high-density lipoprotein in patients on chronic hemodialysis.
OBJECTIVES This study examined the functionality of high-density lipoprotein (HDL) in individuals with end-stage renal disease on dialysis (ESRD-HD). BACKGROUND The high rate of cardiovascular disease (CVD) in chronic kidney disease is not explained by standard risk factors, especially in patients with ESRD-HD who appear resistant to benefits of statin therapy. HDL is antiatherogenic because ...
متن کاملRelationship between High-Density Lipoprotein and C-reactive Protein in Patients with Atherosclerosis
Abstract Background and Objective: Atherosclerosis is an inflammatory disease mostly caused by oxidation of low density lipoproteins (LDLs) while High-density lipoproteins (HDLs) oppose atherosclerosis by inhibiting the oxidation of LDLs. Serum concentration of C- reactive protein (CRP) also increases as an acute phase protein in inflammatory conditions like atherosclerosis. We aimed to evalu...
متن کاملThe effect of carbamylation on the functionality of high-density lipoprotein
Background Increasing interest has focused on the relative functionality of high-density lipoprotein (HDL), highlighted by observations that cardiovascular events can occur even in the presence of high levels of HDL cholesterol. Myeloperoxidase (MPO), a heme protein abundant in leucocytes, colocalizes with HDL in the human artery wall and has emerged as a potential participant in multiple phase...
متن کاملEvalution of In Vitro Effect of Flavonoids on Human Low-Density Lipoprotein Carbamylation
The non-enzymatic carbamylation of low density lipoprotein (LDL) is a naturally occurring chemical modification of apolipoprotein B as a result of condensation between lysine residues and cyanate derived from urea. Carbamylated LDL is poorly recognized by LDL receptors and initiates different processes that can be considered proatherogenic. Thus, LDL carbamylation may contribute to the increase...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Antioxidants & Redox Signaling
سال: 2011
ISSN: 1523-0864,1557-7716
DOI: 10.1089/ars.2010.3640